New study has revealed that sugar can increase the risk of breast cancer and fasten the spread of the disease to the lungs.
Earlier research has identified a link between dietary sugar consumption on breast cancer development, while some studies suggest inflammation plays a vital role. However, no studies have found the direct impact of sugar intake on developing breast cancer in animals.
Therefore, the team set to evaluate the impact of sugar intake on breast cancer in mice. As per the researchers, the amount of sucrose and fructose the mice had was likely to found in western diet – which includes high amount of refined sugars, saturated fat and red meat and low amount of fresh fruits, vegetables and whole grains.
Notably, 50-58% of mice consumed sucrose rich food developed breast cancer. Mice that fed the sucrose- and fructose rich foods are more likely to develop breast cancer when compared to mice that fed the starch-control diet.
Researchers found that the mice fed a sucrose or fructose rich food had more tumors on the lungs when compared to those consumed the starch control diet, recommending high sugar intake speeds up breast cancer metastasis.
The team found that fructose and sucrose- combination of glucose and fructose increased 12-lipoxygenase (12-LOX) signaling, which increased the production of 12-hydroxy-5Z, 8Z, 10E, 14Z-eicosatetraenoic acid (12-HETE) to increase the risk of breast cancer development and metastasis.